Ua pālua ka maʻi osteoarthritis mai ka waena o ke kenekulia 20

ʻO ka osteoarthritis o ka kuli ka maʻi maʻamau, hoʻopau i ka hui pū ʻana me nā kumu i hoʻomaopopo ʻole ʻia akā pili ʻia i ka ʻelemakule a me ka momona.No ka loaʻa ʻana o ka ʻike i ka etiology o ka osteoarthritis kuli, ʻike kēia haʻawina i nā ʻano lōʻihi o ka maʻi ma ʻAmelika Hui Pū ʻIa me ka hoʻohana ʻana i nā ʻāpana iwi nui mai ka wā prehistoric a hiki i kēia manawa.Hōʻike mākou ua lōʻihi ka lōʻihi o ka osteoarthritis o ke kuli ma nā alapine haʻahaʻa, akā mai ka waena o ke kenekulia 20, ua pālua ka maʻi i ka laha.Kūʻē kā mākou mau loiloi i ka manaʻo o ka piʻi ʻana o ka osteoarthritis o ke kuli ma muli wale nō o ka lōʻihi o ka noho ʻana o nā kānaka a ʻoi aku ka nui o ka momona.Akā, hōʻike kā mākou mau hopena i ka pono e aʻo i nā mea ʻē aʻe, hiki ke pale ʻia i nā mea pilikia i lilo i mea maʻamau i loko o ka hapalua kenekulia i hala.

Manaʻo ʻia ka maʻi osteoarthritis i kēia lā ma muli o ka piʻi ʻana o ka manaʻolana o ke ola a me ka helu helu kino kino (BMI), akā ʻaʻole i hoʻāʻo ʻia kēia manaʻo me ka hoʻohana ʻana i ka ʻikepili mōʻaukala lōʻihi a i ʻole evolutionary.Ua kālailai mākou i nā ʻano lōʻihi o ke kuli OA prevalence ma ʻAmelika Hui Pū ʻIa me ka hoʻohana ʻana i nā iwi i loaʻa i ka cadaver o ka poʻe ≥50 y nona ka BMI i ka make i kākau ʻia a ola i ka wā o ka ʻoihana mua (1800s a hiki i ka 1900s mua;n= 1,581) a me ke au postindustrial hou (i ka hopena o 1900s a hiki i ka 2000s mua;n= 819).Knee OA ma waena o ka poʻe i manaʻo ʻia he ≥50 y ka makahiki i loiloi ʻia i loko o nā ʻiʻo archeologically derived of prehistoric hunter-gatherers a me nā mahiʻai mua (6000-300 BP;n= 176).Ua ʻike ʻia ʻo OA ma muli o ka loaʻa ʻana o ke kuni ʻana (polani mai ka pilina iwi-i-iwi).Ma keʻano holoʻokoʻa, ʻike ʻia ka nui o ka OA o ke kuli he 16% ma waena o ka laʻana postindustrial akā ʻo 6% a me 8% wale nō ma waena o nā ʻano hana mua a me nā prehistoric.Ma hope o ka hoʻomalu ʻana i ka makahiki, BMI, a me nā ʻano ʻē aʻe, ʻoi aku ka nui o ka OA o ke kuli i ka 2.1-fold (95% confidence interval, 1.5-3.1) i ka laʻana postindustrial ma mua o ka hoʻohālike ʻoihana mua.Hōʻike kā mākou mau hopena i ka piʻi ʻana o ka lōʻihi a me ka BMI ʻaʻole lawa e wehewehe i ka pālua ʻana o ka nui o ka OA kuli i hana ʻia ma ʻAmelika Hui Pū ʻIa mai ka waena o ke kenekulia 20.No laila ʻoi aku ka pale ʻana o Knee OA ma mua o ka mea i manaʻo ʻia, akā e koi ʻia ka pale ʻana i ka noiʻi ʻana i nā mea pilikia kūʻokoʻa kūʻokoʻa i kū mai a i hoʻonui ʻia i ka wā postindustrial.