Nā hopena a me ka palekana o ka hui pū ʻana o ka platelet-rich plasma (PRP) a me ka hyaluronic acid (HA) i ka mālama ʻana i ka osteoarthritis kuli: kahi loiloi ʻōnaehana a me ka meta-analysis.

Knee osteoarthritis (KOA) he maʻi degenerative kuli maʻamau i hōʻike ʻia e ka cartilage degeneration, cartilage exfoliation, a me subchondral iwi hyperplasia, e alakaʻi ana i ka ʻeha o ke kuli, ka hui pū ʻana a me nā palena hana.Hoʻopilikia koʻikoʻi ʻo KOA i ka maikaʻi o ke ola o ka poʻe maʻi a he pilikia koʻikoʻi ke olakino lehulehu.Ua hōʻike ʻia kahi noiʻi epidemiological i paʻi ʻia ma Proceedings of the National Academy of Sciences (PNAS) ua pālua ʻia ka ulu ʻana o KOA i ka heluna US mai ka waena o ka makahiki iwakālua.Ua lilo ʻo KOA i maʻi nui o ke kanaka a ua hoʻopilikia maikaʻi ʻia i ke ola a me ka hana o nā kānaka.

Manaʻo ka Osteoarthritis Society International (OARSI) i ka mālama conservative ma mua o ke kaʻe ʻana ma ke ʻano he hopena hoʻokele laina mua no KOA, kahi e hoʻoikaika ai i ka pono o ka mālama conservative i ka mālama ʻana iā KOA.Ua manaʻo ka American College of Rheumatology (ACR) i ka hoʻokaʻawale ʻana i ka mālama conservative e pili ana i ka lāʻau lapaʻau a me ka lāʻau lapaʻau ʻole.ʻO ka hoʻomaʻamaʻa ʻole ʻana i ka lāʻau lapaʻau e pili ana i ka hoʻomaʻamaʻa maʻamau a me ka hoʻoikaika kino, akā hilinaʻi nui nā ʻano lāʻau ʻole i ka hoʻokō ʻana o ka mea maʻi a paʻakikī hoʻi ke hoʻopaʻapaʻa.ʻO nā lāʻau lapaʻau nui e pili ana i nā analgesics, nā lāʻau anti-inflammatory non-steroidal a me nā injections corticosteroid.ʻOiai ʻoi aku ka maikaʻi o nā lāʻau lapaʻau ma luna i kekahi pae, aia kekahi mau hopena ʻaoʻao nui.I nā makahiki i hala iho nei, ua hoʻonui nui ʻia nā noiʻi e pili ana i ka hoʻohana ʻana i ka intra-articular injection o ka platelet-rich plasma (PRP) a i ʻole hyaluronic acid (HA) i ka mālama ʻana iā KOA.He nui nā manaʻo loiloi e hōʻike ana i ka intra-articular injection o PRP, i hoʻohālikelike ʻia me HA, hiki ke hoʻohaʻahaʻa i nā hōʻailona ʻeha a hoʻomaikaʻi i ka hana kuli i nā maʻi me KOA.Eia naʻe, ua hōʻike ʻia kahi hoʻokolohua hoʻāʻo ʻelua makapō me kahi 5-makahiki hahai i ka hui pū ʻana o HA a me PRP i hoʻomaikaʻi i ka ʻeha a me ka hana i nā maʻi me ka mōʻaukala o nā loli degenerative knee symptomatic maʻi a me ka osteoarthritis.Ua hōʻike ʻia kahi RCT he mea lapaʻau maikaʻi ka PRP no ka KOA haʻahaʻa a haʻahaʻa a ʻoi aku ka maikaʻi o ka hoʻohana ʻana o HA a me PRP ma mua o ka hoʻohana ʻana i ka HA (1 makahiki) a me PRP (3 mahina) wale nō.Ua hōʻike pū ka RCT ʻaʻole hāʻawi ʻo PRP i ka hoʻomaikaʻi maikaʻi ʻoi aku ka maikaʻi ma mua o HA ma ke ʻano o ka hoʻomaikaʻi ʻana i ka hōʻailona ma nā wahi like ʻole a i ʻole ka lōʻihi o ka hopena.I nā makahiki i hala iho nei, ua hoʻonui ka nui o nā haʻawina i ka noʻonoʻo o ka PRP i hui pū ʻia me HA no KOA, a ua kūkākūkā hohonu ko lākou mau hana.ʻO nā haʻawina hoʻokolohua e hoʻohālikelike ana i ka hiki o ka neʻe ʻana o nā tendon cell a me nā synovial fibroblasts i loko o ka solution PRP maʻemaʻe a me ka PRP me ka solution HA ua hōʻike i ka hui ʻana o PRP me HA hiki ke hoʻomaikaʻi nui i ka neʻe ʻana o ke kelepona.Uaʻikeʻo Marmotti i ka hoʻohuiʻana o HA i ka PRP hiki ke hoʻoikaika maikaʻi i ka hoʻonuiʻana o nā chondrocytes a hoʻonui i ka hiki ke hoʻoponopono i ka cartilage.Ua hōʻike nā haʻawina e hiki i ka hui pū ʻana o PRP a me HA ke pōmaikaʻi mai kāna mau ʻano hana olaola like ʻole a hoʻomaʻamaʻa i ka hana o nā molekala hōʻailona e like me nā molekele inflammatory, catabolic enzymes, cytokines a me nā kumu ulu, no laila ke pāʻani nei i ka hana maikaʻi i ka mālama ʻana o KOA.